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1

Zielstrukturen für Antiepileptika: Molekulare Neurobiologie der Epilepsie

Ingo Böhme, Hartmut Lüddens

Journal:

Pharmazie in unserer Zeit

Year:

2007

Language:

german

File:

PDF, 467 KB

german, 2007

2

Function and pharmacology of multiple GABAA receptor subunits

Hartmut Lüddens, William Wisden

Journal:

Trends in Pharmacological Sciences

Year:

1991

Language:

english

File:

PDF, 1.22 MB

english, 1991

3

GabaA Receptors: Pharmacology, Behavioral Roles, and Motor Disorders

Lüddens, Hartmut, Korpi, Esa R.

Journal:

Neuroscientist The

Year:

1996

Language:

english

File:

PDF, 909 KB

english, 1996

4

Zaleplon displays a selectivity to recombinant GABAA receptors different from zolipdem, zopiclone and benzodiazepines

Kerstin Dämgen, Hartmut Lüddens

Journal:

Neuroscience Research Communications

Year:

1999

Language:

english

File:

PDF, 1.04 MB

english, 1999

5

Synthesis of tritium labeled (±)-1-[2(triphenylmethoxy)ethyl]-3-piperidinecarboxylic acid: a possible compound to determine the efficacy of potential GABA transporter substances in vitro

Ralf Schirrmacher, Wilhelm Hamkens, Hartmut Lüddens, Dr. Frank Rösch

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2000

File:

PDF, 892 KB

2000

6

Radiosynthesis of (±)-(2-((4-(2-[18F]fluoro-ethoxy)phenyl)bis(4-methoxy-phenyl)methoxy)ethylpiperidine-3-carboxylic acid: a potential GAT-3 PET ligand to study GABAergic neuro-transmission in vivo

Ralf Schirrmacher, Wilhelm Hamkens, Markus Piel, Ulrich Schmitt, Hartmut Lüddens, Christoph Hiemke, Frank Rösch

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

7

Synthesis and evaluation of 5,7-dichloro-4-(3-{4-[4-(2-[18F]fluoroethyl)-piperazin-1-yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid as a potential NMDA ligand to study glutamatergic neurotransmission in vivo

Markus Piel, Ralf Schirrmacher, Sabine Höhnemann, Wilhelm Hamkens, Beate Kohl, Michaela Jansen, Ullrich Schmitt, Hartmut Lüddens, Gerd Dannhardt, Frank Rösch

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2003

Language:

english

File:

PDF, 133 KB

english, 2003

8

Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous

Esa R. Korpi, Fabian Debus, Anni-Maija Linden, Cécile Malécot, Elli Leppä, Olga Vekovischeva, Holger Rabe, Ingo Böhme, M. Isabel Aller, William Wisden, Hartmut Lüddens

Journal:

Year:

2007

Language:

english

File:

PDF, 698 KB

english, 2007

9

Total synthesis and evaluation of [18F]MHMZ

Matthias M. Herth, Fabian Debus, Markus Piel, Mikael Palner, Gitte M. Knudsen, Hartmut Lüddens, Frank Rösch

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 441 KB

english, 2008

10

Quantification of GABAA receptor subunit mRNAs by non-radioisotopic competitive RT-PCR utilizing plate-based EIA methodology

Mikko Uusi-Oukari, Raymonde Kleinz, Riikka Mäkelä, Hartmut Lüddens, Esa R Korpi

Journal:

Journal of Neuroscience Methods

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

11

Furosemide Action on Cerebellar GABAA Receptors in Alcohol-Sensitive ANT Rats

Riikka Mäkelä, Mikko Uusi-Oukari, Simo S Oja, Hannu Alho, Ion Anghelescu, Christoph Klawe, Hartmut Lüddens, Esa R Korpi

Journal:

Year:

1999

Language:

english

File:

PDF, 436 KB

english, 1999

12

Phenotypic and Genotypic Analysis of Rats with Cerebellar GABAA Receptors Composed from Mutant and Wild-Type α6 Subunits

Riikka Mäkelä, Garry Wong, Hartmut Lüddens, Esa R. Korpi

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 843 KB

english, 1995

13

Subtype specificity of γ-aminobutyric acid type A receptor antagonism by clozapine

Esa R. Korpi, Garry Wong, Hartmut Lüddens

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.11 MB

english, 1995

14

The diversity of GABAAreceptors

Wulf Hevers, Hartmut Lüddens

Journal:

Molecular Neurobiology

Year:

1998

Language:

english

File:

PDF, 5.05 MB

english, 1998

15

[18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors

Gerhard Gründer, Thomas Siessmeier, Christian Lange-Asschenfeldt, Ingo Vernaleken, Hans-Georg Buchholz, Peter Stoeter, Alexander Drzezga, Hartmut Lüddens, Frank Rösch, Peter Bartenstein

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

16

Evidence for a Reduction of Coupling between GABAAReceptor Agonist and Ionophore Binding Sites by Inorganic Phosphate

Saku T. Sinkkonen, Holger Rabe, Hartmut Lüddens, Esa R. Korpi

Journal:

Neurochemical Research

Year:

2005

Language:

english

File:

PDF, 420 KB

english, 2005

17

Enhanced behavioral sensitivity to the competitive GABA agonist, gaboxadol, in transgenic mice over-expressing hippocampal extrasynaptic α6β GABAA receptors

Kati S. Saarelainen, Martin Ranna, Holger Rabe, Saku T. Sinkkonen, Tommi Möykkynen, Mikko Uusi-Oukari, Anni-Maija Linden, Hartmut Lüddens, Esa R. Korpi

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 500 KB

english, 2008

18

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

Lüddens, Hartmut, Pritchett, Dolan B., Köhler, Martin, Killisch, Iris, Keinänen, Kari, Monyer, Hannah, Sprengel, Rolf, Seeburg, Peter H.

Journal:

Year:

1990

File:

PDF, 549 KB

1990

19

Furosemide interactions with brain GABAA receptors

Esa R Korpi, Hartmut Lüddens

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 730 KB

english, 1997

20

Biological function of GABAA/benzodiazepine receptor heterogeneity

Hartmut Lüddens, Esa R. Korpi

Journal:

Journal of Psychiatric Research

Year:

1995

Language:

english

File:

PDF, 1.28 MB

english, 1995

21

Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation

Elli Leppä, Anni-Maija Linden, Holger Rabe, Olga Yu. Vekovischeva, Peer Wulff, Hartmut Lüddens, William Wisden, Esa R. Korpi

Journal:

European Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.35 MB

english, 2011

22

Coupling between agonist and chloride ionophore sites of the GABAA receptor: agonist/antagonist efficacy of 4-PIOL

Holger Rabe, Raymonde Picard, Mikko Uusi-Oukari, Wulf Hevers, Hartmut Lüddens, Esa R. Korpi

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 290 KB

english, 2000

23

The main determinant of furosemide inhibition on GABAA receptors is located close to the first transmembrane domain

Carolin Jackel, Raymonde Kleinz, Riikka Mäkelä, Wulf Hevers, Sylvie Jezequel, Esa R. Korpi, Hartmut Lüddens

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 157 KB

english, 1998

24

Behavioral Effects of GABAA Receptor Stimulation and GABA-Transporter Inhibition

Ulrich Schmitt, Hartmut Lüddens, Christoph Hiemke

Journal:

Pharmacology Biochemistry and Behavior

Year:

2000

Language:

english

File:

PDF, 69 KB

english, 2000

25

GABAA antagonists reveal binding sites for [35S]TBPS in cerebellar granular cell layer

Esa R. Korpi, Hartmut Lüddens, Peter H. Seeburg

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 158 KB

english, 1992

26

Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor α4 subunit

William Wisden, Anne Herb, Heike Wieland, Kari Keinänen, Hartmut Lüddens, Peter H. Seeburg

Journal:

Year:

1991

Language:

english

File:

PDF, 507 KB

english, 1991

27

Autoradiographic imaging of altered synaptic αβγ2 and extrasynaptic αβ GABAA receptors in a genetic mouse model of anxiety

Saku T Sinkkonen, Bernhard Lüscher, Hartmut Lüddens, Esa R Korpi

Journal:

Neurochemistry International

Year:

2004

Language:

english

File:

PDF, 329 KB

english, 2004

28

The novel anxiolytic ELB139 displays selectivity to recombinant GABAA receptors different from diazepam

Holger Rabe, Christiane Kronbach, Chris Rundfeldt, Hartmut Lüddens

Journal:

Neuropharmacology

Year:

2007

Language:

english

File:

PDF, 181 KB

english, 2007

29

Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [18F]MH.MZ

Matthias M. Herth, Markus Piel, Fabian Debus, Ulrich Schmitt, Hartmut Lüddens, Frank Rösch

Journal:

Nuclear Medicine and Biology

Year:

2009

Language:

english

File:

PDF, 614 KB

english, 2009

30

18F-Labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging

Fabian Debus, Matthias M. Herth, Markus Piel, Hans-Georg Buchholz, Nicole Bausbacher, Vasko Kramer, Hartmut Lüddens, Frank Rösch

Journal:

Nuclear Medicine and Biology

Year:

2010

Language:

english

File:

PDF, 932 KB

english, 2010

31

Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors

Garry Wong, Mikko Kuoppamäki, Jarmo Hietala, Hartmut Lüddens, Erkka Syvälahti, Esa R. Korpi

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 396 KB

english, 1996

32

Characterization of γ-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions

Saku T. Sinkkonen, Mikko Uusi-Oukari, Erkki Tupala, Terttu Särkioja, Jari Tiihonen, Pertti Panula, Hartmut Lüddens, Esa R. Korpi

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 1.41 MB

english, 2001

33

Altered atypical coupling of γ-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines

Saku T. Sinkkonen, Robert M. Mihalek, Gregg E. Homanics, Hartmut Lüddens, Esa R. Korpi

Journal:

Molecular Brain Research

Year:

2001

Language:

english

File:

PDF, 2.90 MB

english, 2001

34

Behavioral analysis indicates benzodiazepine-tolerance mediated by the benzodiazepine binding-site at the GABAA-receptor

Ulrich Schmitt, Hartmut Lüddens, Christoph Hiemke

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

2001

Language:

english

File:

PDF, 977 KB

english, 2001

35

Drug interactions at GABAA receptors

Esa R Korpi, Gerhard Gründer, Hartmut Lüddens

Journal:

Progress in Neurobiology

Year:

2002

Language:

english

File:

PDF, 1.56 MB

english, 2002

36

GABA: Receptors, transporters and metabolism: Ch. Tanaka and N.G. Bowery (Editors). Birkhäuser, Basel, 1996. ISBN 3-7643-5284-1; DM168.00

Hartmut Lüddens

Journal:

Journal of Chemical Neuroanatomy

Year:

1996

Language:

english

File:

PDF, 175 KB

english, 1996

37

Structure–activity relationship of furosemide-derived compounds as antagonists of cerebellum-specific GABAA receptors

Hartmut Lüddens, Hans-J Lang, Esa R Korpi

Journal:

European Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 251 KB

english, 1998

38

Organotypic rat cerebellar slice culture as a model to analyze the molecular pharmacology of GABAA receptors

Eugen Davids, Wulf Hevers, Kerstin Dämgen, Kehong Zhang, Frank I Tarazi, Hartmut Lüddens

Journal:

European Neuropsychopharmacology

Year:

2002

Language:

english

File:

PDF, 1.04 MB

english, 2002

39

NMDA receptor channels: Subunit-specific potentiation by reducing agents

Köhr, Georg, Eckardt, Sigrid, Lüddens, Hartmut, Monyer, Hannah, Seeburg, Peter H.

Journal:

Year:

1994

Language:

english

File:

PDF, 1.06 MB

english, 1994

40

Probing the central type benzodiazepine binding site by use of receptor subtype mutants

Lüddens, Hartmut, Seeburg, Peter H.

Journal:

European Neuropsychopharmacology

Year:

1993

Language:

english

File:

PDF, 277 KB

english, 1993

41

Expression patterns of GABAA receptor subtypes in developing hippocampal neurons

Killisch, Iris, Dotti, Carlos G., Laurie, David J., Lüddens, Hartmut, Seeburg, Peter H.

Journal:

Year:

1991

Language:

english

File:

PDF, 11.86 MB

english, 1991

42

Subunit Selectivity and Epitope Characterization of mAbs Directed against the GABAA/Benzodiazepine Receptor

Markus Ewert, Brenda D. Shivers, Hartmut Lüddens, Hanns Möhler and Peter H. Seeburg

Journal:

The Journal of Cell Biology

Year:

1990

Language:

english

File:

PDF, 1.16 MB

english, 1990

43

Proteomic identification of the heterogeneous nuclear ribonucleoprotein K as irradiation responsive protein related to migration

Strozynski, Judith, Heim, Julia, Bunbanjerdsuk, Sacarin, Wiesmann, Nadine, Zografidou, Lea, Becker, Simone Katharina, Meierl, Anna-Maria, Gouveris, Haralampos, Lüddens, Hartmut, Grus, Franz, Brieger,

Journal:

Journal of Proteomics

Year:

2015

Language:

english

File:

PDF, 1.42 MB

english, 2015

44

More Than one Alpha Variant May Exist in a Gaba A /benzodiazepine Receptor Complex

Lüddens, Hartmut, Killisch, Iris, Seeburg, Peter H.

Journal:

Journal of Receptor and Signal Transduction Research

Year:

1991

Language:

english

File:

PDF, 739 KB

english, 1991

45

Selective binding to monoamine oxidase A: In vitro and in vivo evaluation of 18F-labeled β-carboline derivatives

Schieferstein, Hanno, Piel, Markus, Beyerlein, Friderike, Lüddens, Hartmut, Bausbacher, Nicole, Buchholz, Hans-Georg, Ross, Tobias L., Rösch, Frank

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.56 MB

english, 2015

46

Characterization of the Porcine ACTH Receptor with the Aid of a Monoclonal Antibody

LÜDDENS, Hartmut, HAVSTEEN, Bent

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1986

File:

PDF, 2.13 MB

1986

47

GABA A -receptor Subtypes: Clinical Efficacy and Selectivity of Benzodiazepine Site Ligands

Korpi, Esa R., Mattila, Mauri J., Wisden, William, Luddens, Hartmut

Journal:

Annals of Medicine

Year:

1997

Language:

english

File:

PDF, 794 KB

english, 1997

48

The Inhibitory Neural Circuitry as Target of Antiepileptic Drugs

Bohme, Ingo, Luddens, Hartmut

Journal:

Current Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 133 KB

english, 2001

49

The Third γ Subunit of the γ-Aminobutyric Acid Type A Receptor Family

Anne Herb, William Wisden, Hartmut Luddens, Giulia Puia, Stefano Vicini and Peter H. Seeburg

Journal:

Proceedings of the National Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 1.46 MB

english, 1992

50

Early life stress is a risk factor for excessive alcohol drinking and impulsivity in adults and is mediated via a CRF/GABA A mechanism

Gondré-Lewis, Marjorie C., Warnock, Kaitlin T., Wang, Hong, June, Harry L., Bell, Kimberly A., Rabe, Holger, Tiruveedhula, Veera Venkata Naga Phani Babu, Cook, James, Lüddens, Hartmut, Aurelian, Laure

Journal:

Year:

2016

Language:

english

File:

PDF, 909 KB

english, 2016

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